摘要:Most biologic therapeutics are large, complex molecules or heterogeneous mixtures of molecules that are manufactured in a living system (e.g., microorganism, plant cell, or animal cell) through recombinant DNA technology. Biologics are now being used to treat a wide range of diseases, including cancer, autoimmune disorders, and diabetes. It is estimated that half of the top 100 best-selling medications will soon be biologics, with Roche s anticancer biologic Avastin and AbbVie s anti-inflammatory antibody Humira rivaling the success of Pfizer s small-molecule drug Lipitor (1). Biologics differ fundamentally from small-molecule drugs in terms of purity, composition, and production. Small-molecule drugs typically have homogeneous, well-defined structures that have been finely tuned with atomic-level precision via chemical synthesis. On page 1357 of this issue, Wang et al. (2) bridge the gap between biologics and small-molecule drugs by accomplishing the total chemical synthesis of the biologic erythropoietin (EPO) in a single, pure form.
(2) bridge the gap between biologics and small-molecule drugs by accomplishing the total chemical synthesis of the biologic erythropoietin (EPO) in a ...劳动关系学院,包括图书馆概况,开放时间,检索向导,馆藏分布,书目查询,新书报道,电子资源,图书馆指南,读者服务等。中国劳动关系学院 中国劳动关系学院图书馆 劳动关系学院图书馆 中国工运学院 中国工运学院图书馆 全总干校 劳动关系Improving Biologic Drugs via Total Chemical Synthesis
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